Apoptosis is one of the major mechanisms for the killing effect exerted by BETis in cancer cells.11, 12 The involvement of the GSK3β/Fbw7/proteasome pathway has also been reported in BETi‐mediated cell death in various cancers.13, 14 However, the involvement of this pathway in the therapeutic effect of BETis in BC remains to be corroborated. This evidence concerns the gene GSK3B and cancer.