The tumour‐suppressive functioning of FBW7 in several mouse and human cancers is known.15, 16 It is an F‐box protein comprising a key element of the SCF (SKP1‐CUL1‐F‐box) E3 ligase complex that functions in protein ubiquitination and degradation,17 including cyclin E1, c‐Jun, c‐Myc, Notch1 and Mcl‐1.18 The gene discussed is FBXW7; the disease is cancer.