The postulated mechanism of action of these compounds against COVID-19 is through increasing the pH of endosomes, lysosomes, and the cell membrane surface, thereby preventing the fusion of the virus with host cells and subsequent replication [1, 2] or by interfering with the glycosylation of angiotensin-converting enzyme 2 (ACE2) to reduce the binding efficiency between host cells and the spike protein on the surface of the coronavirus [4]. This evidence concerns the gene ACE2 and COVID-19.