LMNB1 and liver cancer: While some study reported that increased lamin B1 expression is related to a more aggressive and invasive phenotype (in pancreatic and liver cancer [67, 68]) and importantly, that overexpression of lamin B1 is accompanied by a bad prognosis (in renal and gastric cancers [69, 70]), a decrease of lamin B expression has been also associated with greater aggressiveness and bad prognosis (in lung and breast cancer [71, 72]).