LMNB1 and adult-onset autosomal dominant demyelinating leukodystrophy: About this, Bartoletti-Stella et al. suggest that ADLD could be considered as a “spliceopathy” caused by increased levels of lamin B1 and raver2 and that the characteristic demyelination could be the result of increased expression, during adulthood, of the embryonic isoform of the PLP1 protein, which has a crucial role in myelin maintenance.