This event maintains the nuclear localization of FOXO1 and induces increases in the transcription and translation of G6pase and PCK1, two gluconeogenetic genes, giving rise to glucose overproduction in the liver and hyperglycaemia and uncovering a mechanism by which VD deficiency eventually leads to chronic hyperglycaemia and hepatic insulin resistance. The gene discussed is FOXO1; the disease is Hyperglycemia.