Mutt et al. [38] reported that long-term VD deficiency caused hepatic insulin resistance through impairing the PI3K-AKT-FOXO1 pathway while VD ameliorated the above dysfunction via activating the AKT/GSK3β and AKT/FOXO1 signaling pathways, which was consistent with our findings. The gene discussed is FOXO1; the disease is Insulin resistance.