Further analysis of the downstream gene expression of the Wnt/β-catenin pathway also demonstrated that LINC02273 KD led to the suppression of the transcriptional activity of β-catenin, where the proved downstream genes, such as c-Myc, Cyclin D1, Survivin, MMP-7, and COX-2, were observed to be downregulated after LINC02273 interference (Figure 5(c)) [23, 24], suggesting that LINC02273 might potentiates the proliferation, stemness, invasion, migration, and survival of HCC cells. The gene discussed is CCND1; the disease is hepatocellular carcinoma.