Compared with kidney endothelial cells, two endothelial cell subpopulations were expressing a higher level of genes for three pathways closely linked to either stroke or depression, suggesting that these cells could be made susceptible to the disease by the upregulated expression of Ube2g1, Pdcd4, Fnbp4, Tollip, and Faf1. Here, UBE2G1 is linked to major depressive disorder.