At the same time, the imbalance of β-CGRP/α-CGRP regulated AQP5 expression and promoted transition of alveolar epithelial cell apoptosis via the TGF-β/P-smad1/Smad4 pathway leading to a decreased AQP5 expression in pulmonary fibrosis [80]. This evidence concerns the gene TGFB1 and pulmonary fibrosis.