MAP1LC3B and periodontal disorder: In accordance with our results, Evans et al. found that butyrate induced autophagy-dependent cell apoptosis of human gingival epithelial cell Ca9-22 to alleviate periodontal disease, as indicated by activating AMPK and inducing the production of LC3B, which was attenuated by AMPK inhibition; in addition, interference with LC3B gene could also significantly inhibit butyrate-induced cell death [44].