Yu et al. [175] found that lobaplatin-induced pyroptosis of colon cancer cells is dependent on GSDME and knocking out GSDME leads to the conversion of lobaplatin-induced pyroptosis to apoptosis but it does not affect the inhibitory effect of lobaplatin on cell growth in vitro or on tumor formation in vivo. The gene discussed is GSDME; the disease is colonic neoplasm.