NLRC4 and Salmonella Infections: Among them, NAIP2 binds to the rod protein T3SS [98–100], NAIP1 binds to the needle tube proteins of the T3SS, and NAIP5 and NAIP6 bind to bacterial flagellin and then bind to NLRC4 to promote the activation of caspase-1 and (2) Ser533 in NLRC4 is phosphorylated and activated after Salmonella infection [101, 102].