Integrative analysis of common deregulated miRNAs in H. pylori-associated peptic ulcer and periodontitis-affected tissues revealed key candidate linkage molecular mechanisms comprising of miRNAs (including hsa-mir-155-5p, hsa-mir-484, and hsa-mir-29a-3p), genes (including PTEN, CCND1, MDM2, TNRC6A, and SCD), and TF targets (including STAT3, HIF1A, EZH2, CEBPA, and RUNX1) and highlighted the most relevant compounds (including curcumin, 5-fluorouracil, and 1,2,6-tri-O-galloyl-beta-D-glucopyranose) in this context. The gene discussed is EZH2; the disease is peptic ulcer disease.