We found that the levels of IL-6 and TNF-α in gastrocnemius of mice in model group gastrocnemius were significantly higher than those in the healthy group, while curcumin partially inhibited elevated levels of IL-6 and TNF-α in tumor-bearing mice, which indicate the anti-inflammation ability of curcumin in TNBC-cachexia. This evidence concerns the gene TNF and neoplasm.