Together, the latter indicates that, while the majority of the genes affected by the presence and absence of CTCFL are different, at the functional level, many of these genes belong to the same protein families or participate in the same cellular processes; i.e., cell motility (cytoskeleton), and membrane transport, which are well-known mechanisms associated with the development of metastases27,28 and tumor resistance to drugs29,30; suggesting that CTCFL could play an important role in OC metastases. The gene discussed is CTCFL; the disease is neoplasm.