CD274 and neoplasm: For example, the dual blockage of the PD-1/PD-L1 axis and CD47-SIRPα axis has been incorporated into single BsAbs, namely, IBI322 (PD-L1 × CD47) and HX009 (PD-1 × CD47), to simultaneously potentiate the local adaptive and innate immune responses against tumor cells and is being evaluated in phase I trials (NCT04338659 and NCT04097769 for IBI322 and HX009, respectively).175