FCGR3A and neoplasm: NK cells have been identified as playing indispensable roles in the innate immune system, and growing evidence has demonstrated their ability to reduce tumor load and exert tumor immunosurveillance.136 CD16 (FcγRIII), mainly expressed on mature NK cells, is a low-affinity receptor that binds with the Fc domain of IgG antibodies to mediate ADCC.