TNFRSF8 and anaplastic large cell lymphoma: Based on results from the ECHELON-1 and ECHELON-2 trials, BV showed potent single-agent activity, and BV in combination with chemotherapy agents was shown to be more effective than chemotherapy alone.55,56 Hence, the FDA expanded approval of BV in combination with chemotherapy for the first-line treatment of stage III or IV classical HL or for previously untreated systemic ALCL or other CD30-expressing peripheral T cell lymphomas.