A modified anticalin specifically binds to fibronectin ED-B,293 which can be used for the diagnosis of glioblastomas.294 ED-B-specific anticalins are located in the blood vessels of a glioblastoma, especially in the endothelial cells of glioblastoma origin.294 On the other hand, anticalins can be used to construct BsAbs for binding targets. Here, FN1 is linked to glioblastoma.