IL36RN and ectodermal dysplasia syndrome: This includes evidence for the development and maintenance of the pilosebaceous unit, indicated by the presence of several ectodermal dysplasia genes at acne risk loci, and also neutrophilic inflammation evidence by the presence of an acne susceptibility association signal at the IL36RN locus at which rare loss of function alleles have been associated with a series of pustular skin phenotypes21,22,24.