The support for these cellular processes arises from several putative causal genes previously implicated at established acne susceptibility loci, including LAMC2, TGFB2, WNT10A, LGR6, FGF2 and GLI2 but also highlights the potential consistency of biological processes involved in acne pathogenesis with the identification of other members of these gene sets located near new acne association signals. The gene discussed is GLI2; the disease is acne.