We found two significant associations: in CheckMate 009/RCC, patients with higher Myeloid Inflammation score at baseline experienced significantly greater increase in sPD-L1 (p=0.018, figure 6A), and in CheckMate 038-P1/melanoma, patients with lower EMT/stroma score at baseline experienced significantly greater increase in sPD-L1 (p=0.017, figure 6B). Here, SPDL1 is linked to melanoma.