With respect to the relationship between the level of baseline sPD-L1 and transcripts encoding 60 metalloproteases, ADAM11, ADAM20 and ADAMTS14 were identified as associated with higher baseline sPD-L1 levels in both CheckMate 009/RCC and CheckMate 038-P1/melanoma (t-values >1.5, figures 3E and 4D, online supplemental table S7). The gene discussed is SPDL1; the disease is renal cell carcinoma.