Six Hallmark gene sets were enriched with the same direction in GSEA results from both RCC and melanoma: high baseline sPD-L1 is associated with lower expression of genes from ‘Hypoxia’, ‘Fatty Acid Metabolism’, ‘Glycolysis’, ‘MTORC1 signaling’ and ‘Androgen Response’, and with higher expression of genes from ‘KRAS signaling_Down’. This evidence concerns the gene SPDL1 and renal cell carcinoma.