Interestingly, high baseline sPD-L1 is associated with higher expression of genes from ‘KRAS signaling_Down’ and lower expression of genes from ‘Hypoxia’, ‘Fatty Acid Metabolism’, ‘Glycolysis’, ‘MTORC1 signaling’ and ‘Androgen Response’ processes in both RCC and melanoma, suggesting that high sPD-L1 is distinct from a number of potentially targetable pathways. Here, SPDL1 is linked to renal cell carcinoma.