Our results of univariate modeling, clustering, and ML prediction point towards a distinct long-term pulmonary risk phenotype that manifests during acute COVID-19 and early recovery and whose central components are protracted systemic (IL-6, CRP, anemia of inflammation) and microvascular inflammation (D-dimer), and strong humoral response (anti-S1/S2 IgG) demographic risk factors and comorbidities (Sonnweber et al., 2020)⁠. The gene discussed is IL6; the disease is COVID-19.