The differential diagnosis of ChAc includes McLeod syndrome (MLS), pantothenate kinase-associated neurodegeneration (PKAN), Huntington’s disease-like 2 (HDL2), other forms of inherited chorea (such as Huntington's disease), other forms of Huntington-like disorders, other syndromes of neurodegeneration with brain iron accumulation (NBIAs), Wilson disease, and acquired conditions caused by infection, immunization, drugs, etc. Currently, the treatment of ChAc is limited, mainly drugs and deep brain stimulation (DBS) are used to relieve its symptoms. Here, PANK1 is linked to McLeod neuroacanthocytosis syndrome.