IL6 and pulmonary arterial hypertension: Finally, in the mouse model of PAH, which was induced by the combinatorial treatment of hypoxia and Sugen (SU5416, a VEGF receptor blocker), sulfasalazine administration significantly reduced the muscularization of peripheral pulmonary arteries (vascular remodeling) and the proportion of CD44v+ vessels, along with a decrease in EndoMT cells and decreased expression levels of inflammation-related genes, such as TNFA, IL1B, and IL6.