TET1 regulated the expression of TβRII and TSP1 at the epigenetic level, presumably by the demethylation of the promoter of TGFBR2 and TSP1. The streptozotocin (STZ) model was used to induce hyperglycemia, thereby causing endothelial dysfunction and an enhanced inflammatory response, as suggested by TNF-α upregulation. Here, TGFBR2 is linked to endothelial dysfunction.