Grade 3 TRAEs were uncommon with 2 events in each of Mild, Sev (1 mg) and Sev (1.5 mg) liver dysfunction groups (grade 3 alanine aminotransferase and gamma-glutamyl transferase increased in Mild group; grade 3 lymphopenia and maculopapular rash in Sev (1 mg) group; grade 3 acneiform rash and fatigue in Sev (1.5 mg) group). The gene discussed is GPT; the disease is lymphopenia.