HNRNPU and urinary bladder carcinoma: The upregulated genes were enriched in cell cycle-related pathways such as “Meiosis,” “Meiotic recombination,” “Cell cycle” as well as DNA repair pathways such as “double-strand break repair” and “ATM pathway.” These results demonstrate that HNRNPU knockout could rewire the transcriptome of bladder cancer cells, resulting in increased vulnerability to cisplatin treatment.