SYK and idiopathic pulmonary fibrosis: Of the 40 genes having clinically available kinase inhibitors, SYK; Bruton tyrosine kinase; cyclin-dependent kinase 4; FGR proto-oncogene, Src family tyrosine kinase; and colony-stimulating factor 1 receptor were upregulated by more than twofold in IPF lung tissues (Fig. 3f).