Recent data suggests that MerTK plays a more significant role in the context of AD, as single mutant APP/PS1 Mertk−/− mice had similar plaque reductions as APP/PS1 Axl−/−Mertk−/− mice, while single mutant APP/PS1 Axl−/− mice were more similar to APP/PS1 mice [15]. Here, MERTK is linked to Alzheimer disease.