In contrast, the baseline concentrations of some apolipoproteins were significantly higher in subjects with new-onset T2D vs. the others: apoC-II (2.84 [2.08; 3.62] vs. 2.46 [1.88; 3.48] mg/dL, OR = 1.35 [1.06–1.70], p = 0.013); apoC-III (6.73 [5.23; 9.22] vs. 6.04 [4.88; 7.51] mg/dL, OR = 1.27 [1.01–1.61], p = 0.043), apoE (7.61 [6.11; 9.14] vs. 6.45 [5.44; 8.35] mg/dL, OR = 1.31 [1.04–1.66], p = 0.023), and apoL1 (1.20 [0.95; 1.52] vs. 1.09 [0.91; 1.28] mg/dL, OR = 1.43 [1.13–1.81], p = 0.0032). This evidence concerns the gene APOL1 and type 2 diabetes mellitus.