APOA2 and type 2 diabetes mellitus: Large cohort studies drawn from the general population have shown that the apolipoprotein (apo)B100-to-LDL-C, apoA-I-to-HDL-C, and apoA-II-to-HDL-C ratios are better predictors of worsening glycemia and incident T2D than LDL-C and HDL-C levels, respectively [15, 16].