After additional adjustment for lipid-lowering therapy (model 3), the baseline plasma concentrations of apoC-I, apoC-II, apoC-III, apoE, apoF, apoH, apoJ, and apoL1 were significantly associated with the conversion to T2D; but only baseline apoE, apoF, apoJ, and L1 remained significant in the last model with additional adjustment for TG (HR: 1.28 [1.06; 1.54], p = 0.010; 1.22 [1.01; 1.48], p = 0.037; 1.24 [1.03; 1.49], p = 0.024; 1.26 [1.05; 1.52], p = 0.014; respectively). This evidence concerns the gene APOE and type 2 diabetes mellitus.