EH was taken as the dependent variable, and each gene and its interaction terms were introduced into the logistic regression equation to analyse the influence of the interactions between ACE, ACE2 and CYP11B2 in the effect on EH based on the multiplicative model after adjustment for confounders such as BMI, family history of hypertension, TG, and TC. The gene discussed is ACE2; the disease is Hypertension.