ACE and hypertensive disorder: There was a negative additive interaction between ACE2 G8790A and CYP11B2-344T/C on EH (U3 =  − 2.221, P = 0.026, and S = 0.128) and a positive multiplicative interaction between ACE I/D and CYP11B2-344T/C on essential hypertension (P = 0.041).