NFKB1 and renal cell carcinoma: Examining the relationship between the expression of NF-κB and that of p53, Ki-67 and p16INK4a, several associations were discovered (Table 8); cytoplasmic NF-κB expression was associated with Ki-67 overexpression (p = 0.012); nuclear NF-κB expression was associated with p53 overexpression (p = 0.027); and there was a negative association between nuclear NF-κB expression and p16INK4a expression in RCC cases (p = 0.001).