When the subgroup having no ARB or ACE inhibitor exposures in the year prior to PC diagnosis were further restricted to those with no comorbid hypertension diagnosis or other antihypertensive medication exposures that year, the associations were stronger for ARBs after PC diagnosis (Supplemental Table S7: HR = 0.65; 95% CI: 0.47, 0.91) and for ACE inhibitors during the first 3 years of survival after PC diagnosis (Supplemental Table S8: HR = 0.72; 95% CI: 0.59, 0.89). The gene discussed is ACE; the disease is Hypertension.