The mortality hazard benefit associated with exposure to ACE inhibitors during the first three years of survival after PC diagnosis appears to be largely driven by the subgroups of patients with no metastatic disease at diagnosis and not resected (HR = 0.83; 95% CI: 0.74, 0.93) and/or those with no ARB or ACE inhibitor exposures in the year prior to their PC diagnosis (HR = 0.78; 95% CI: 0.67, 0.89). This evidence concerns the gene ACE and pachyonychia congenita.