ACE and pachyonychia congenita: Based on a Cox model adjusted for potential confounders (Supplemental Table S6), in comparison to otherwise similar patients, those exposed to ARBs after their PC diagnosis experienced 20% lower mortality hazard (Fig. 1; HR = 0.80; 95% CI: 0.72, 0.89) and those exposed to ACE inhibitors during the first three years of survival after PC diagnosis experienced 13% lower mortality hazard (Fig. 2; HR = 0.87; 95% CI: 0.80, 0.94).