We analyzed the correlation between clinical efficacy and the levels of inflammatory factors through Spearman correlation analysis and found that clinical efficacy gradually declined with the increase of IL-1, IL-6, and TNF-α, which indicated that IL-1, IL-6, and TNF-α can be used as potential outcome measures for clinical efficacy on patients with xerophthalmia. Here, IL6 is linked to Keratoconjunctivitis sicca.