In a subgroup of 7 patients in our study with hand osteomyelitis, rheumatological conditions, and secondary Raynaud phenomenon, CRP was not universally elevated.25,26 Numerous studies have found CRP to be more sensitive than WCC when used to identify bacterial infection,27, -29 and that even minor infections such as small colonized wounds can cause an increase in CRP,30 which may explain increased sensitivity relative to other inflammatory markers. The gene discussed is CRP; the disease is infection.