CXCL1 and colorectal carcinoma: Similar to previous findings with non-CRC-F. nucleatum isolates (30), our CRC- (Fig. 5) and non-CRC-derived (Fig. S6) F. nucleatum strains induced secretion of CXCL1 and IL-8 from HCT116 cells, although the magnitude of chemokine induction differed between strains, even within a given subspecies.