IL1A and Rickettsiosis: in vivo, IL-1α or IL-1β function was neutralized via tail vein (intravenous [i.v.]) injection with anti-IL-1α, anti-IL-1β, or anti-IgG-isotype control antibodies (Abs) into C57BL/6J WT mice in our established model of mild rickettsiosis (LD25; ∼105 PFU) (Fig. 1B to D).