CASP1 and infection: In this effort, BMDMs derived from WT, Casp-1−/−, Casp-11−/−, and Casp-1/11−/− mice were infected with R. typhi, R. rickettsii, and R. montanensis, and the levels of IL-1β and IL-1α and cell death, as well as bacterial burdens, were evaluated over the course of infection.