The misfolding of proteins into insoluble amyloid fibrils causes more than 30 human diseases, such as Alzheimer disease caused by the misfolding of Tau and amyloid β, Parkinson’s disease caused by the misfolding of α-synuclein, and dialysis-related amyloidosis caused by the misfolding of β2-microglobulin (β2M) [1–6]. This evidence concerns the gene B2M and amyloidosis.