B2M and amyloidosis: Thus, deletion of the N-terminal hexapeptide significantly decreases the conformational stability of β2M fibrils and amyloid fibrils formed by ΔN6 are conformationally distinct from that formed by WT β2M. Our data suggest that the instability property of ΔN6 fibrils may lead to an increased capability of propagation, which may be strictly related to the onset of dialysis-related amyloidosis.