Moreover, it has been shown that under high glucose environment both PVT1 and its derivative miR-1207-5p can enhance the expressions of FN1, TGF-β1, and PAI-1 in glomerular mesangial cells independently of each other, thereby increasing ECM accumulation and accelerating the process of renal fibrosis of DN[145]. This evidence concerns the gene TGFB1 and renal fibrosis.