Patient 1 with DIPG exhibited increased levels of immunosuppressive cytokines, including TGFβ, in the CSF (Fig. 4e, Extended Data Fig. 5d) and prominent myeloid populations in tumour tissue (Extended Data Fig. 1f, g), which may correlate with her lack of response. The gene discussed is TGFB1; the disease is diffuse intrinsic pontine glioma.