The AF levels of APRIL, EN-RAGE, LBP, and TNFR2 were significantly correlated with each other (all variables, r = 0.209–0.592, P < 0.01), except for APRIL and EN-RAGE (r = 0.209, P = 0.150), and APRIL and LBP (r = 0.233, P = 0.107). The gene discussed is TNFRSF1B; the disease is atrial fibrillation.