AUC values of AF EN-RAGE, S100A8/A9, and uPA for the prediction of SPTB at < 32 weeks of gestation were 0.744, 0.763, 0.755, and 0.649, respectively (S4 Table and Fig 2), not showing significant differences among them (all variables: P = 0.09–0.66). The gene discussed is PLAU; the disease is atrial fibrillation.