CD8A and systemic lupus erythematosus: In previous studies, SLE patients with predominant skin damage were related to γδ T cells [15,59], while SLE patients with LN were associated with γδ T cells, NK cells, CD8+ T cells, and Tregs [7,25,60] and the pathology of affected tissues such as the skin and kidneys confirmed local damage arising from cellular immunity [59,61].