Moreover, tumor development in the Lgr5-CreER/Apcfl/fl model depends on the activity of the transcription factor Myc [46] and PYCR1 is a Myc target gene [47], suggesting that the enhanced expression of PYCR1 in CRC plausibly results from Myc transcriptional activity. The gene discussed is PYCR1; the disease is colorectal carcinoma.