Hence, ELP probably produces anti-RA effects by synergistically regulating many biological pathways, such as PI3K-Akt signaling pathway, Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, MAPK signaling pathway, TNF signaling pathway, and Toll-like receptor signaling pathway, and so on. Here, AKT1 is linked to rheumatoid arthritis.