In this work, it is found that ELP probably performed anti-RA effects via synergistically regulating many biological pathways, important six such as PI3K-Akt signaling pathway, Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, MAPK signaling pathway, TNF signaling pathway, and Toll-like receptor signaling pathway. The gene discussed is TNF; the disease is rheumatoid arthritis.