2018). Besides, Li et al. reported that geniposide alleviated renal dysfunction in diabetic nephropathy mice through adenosine 5′-monophosphate-activated protein kinase (AMPK)/sirtuin1 (SIRT1)/NF-κB pathway, followed with the decreased levels of TNF-α, IL-6 and IL-1β (Li et al. 2020). In the disorders of atherosclerosis and osteoarthritis, geniposide was also proved to alleviate inflammation by regulating miR-101/mitogen activated protein kinase phosphatase-1 (MKP-1)/p38 pathway (Chen et al. 2018; Cheng et al. 2019). This evidence concerns the gene TNF and diabetic kidney disease.