FABP2 and endothelial dysfunction: Fatty acid-binding proteins (FABPs) are small cytosolic proteins found in mature enterocytes that are released after cell damage and serve as a biomarker of endothelial cell integrity.29 Unfortunately, FABPs are not ideal markers of intestinal permeability and may not reflect other permeability pathways, such as endothelial dysfunction or disruption of tight junctions between endothelial cells, which also occur in cirrhosis.30 This might explain why we failed to observe significant correlations between circulating microbiome signatures and FABP2.