In this study, we have demonstrated that PFD can reverse the formation of EMT induced by TGF-β via inhibiting Smad2/3 phosphorylation and c-Ski degradation, thereby alleviating the migration, invasion and proliferation of renal cancer cells induced by TGF-β through a series of experiments, which broaden the potential usage of PFD in antitumoral therapy, especially for renal cancer. This evidence concerns the gene SMAD2 and renal carcinoma.