In this study, we demonstrate that PFD treatment significantly prevents autocrine TGF-β production and TGF-β-induced EMT, thus inhibiting cancer cell proliferation, migration, and invasion in renal cell carcinoma through reducing activation of R-Smads and degradation of the endogenous TGF-β signaling antagonist c-Ski. Here, TGFB1 is linked to hereditary clear cell renal cell carcinoma.