Moreover, cellular assays disclosed that aCIS and EPI-loaded niosome (NCE) and FA-PEGylated niosomal CIS andEPI (FPNCE) enhanced the apoptosis rate and cell migration in SKBR3and 4T1 cells compared to CIS, EPI, and their combination (CIS+EPI).For FPNCE and NCE groups, the expression levels of Bax, Caspase3, Caspase9, and Mfn1 genes increased, whereas the expression of Bcl2, Drp1, MMP-2, and MMP-9 genes was downregulated. The gene discussed is MMP9; the disease is in situ carcinoma.