PEG, a highly biocompatibleand water-soluble polymer, was used for niosome surface modification.41,43 The functionalization of niosomes with PEG can increase the passivetargeting of anticancer therapeutics and enhance the internalizationof drugs into cancer cells.44,45 FA is one of the bestactive targeting ligands that bind to folate receptors with high affinityand internalize into cells through receptor-mediated endocytosis.41,46 Folate receptors are anchored cell surface receptors that are upregulatedand overexpressed in numerous cancer cell types compared with normalcells.47 The gene discussed is CD177; the disease is cancer.