Examples of these include genetic models of glaucoma (MyocY437H mice), OHT induced by transduction of the TM with glaucoma-related genes (e.g., MYOC, TGFβ2, GREM1, CTGF, DKK1, SFRP1, CD44, Cre and inducible transgene models, genome editing),49–56 as well as glucocorticoid-induced OHT models.14 The gene discussed is SFRP1; the disease is glaucoma.