There is astudy suggested that HMGB2 is associated with malignancy and regulates Warburgeffect in human breast cancer by targeting lactate dehydrogenase B andfructose-bisphosphatase 1 (Fu et al., 2018).HMGB2 is expressed in patients with OC and associated with prognosis and tumormetastasis (Ouellet et al., 2006). The gene discussed is HMGB2; the disease is breast cancer.