Using RT-PCR, we found that the level of hsa_circ_012448 was increased in cell culture in DKD and regulated hsa-miR-29b-2-5p-GSK3β signaling, indicating that hsa_circRNA_012448-hsa-miR-29b-2-5p-GSK3β may be a potential pathway for dapagliflozin in protecting DKD. This evidence concerns the gene GSK3B and diabetic kidney disease.