VEGFA and cancer: However, in the dapagliflozin group, the role of DEcircRNAs was closely related to the Rap1 signaling pathway, transcriptional misregulation in cancer, and protein processing in the endoplasmic reticulum (Figure 3f), whereas metformin was associated with the MAPK and PI3K-Akt signaling pathways (Figure 3g), and vildagliptin participated in the HIF-1 signaling pathway, focal adhesion and VEGF signaling pathways (Figure 3h).