NLRP3 and osteoarthritis: Some of the recent examples include: lncRNA OASL-IT1 and interferon loop system that regulates antiviral defense against Zika Virus [18]; lncRNA NLRP3 promotes NLRP3-triggered inflammatory response in early acute lung injury by binding to miR-138-5p [19]; mRNA-lncRNA crosstalk is involved in immune regulation of carp macrophages [20]; lncRNA THUMPD3-AS1 is downregulated in osteoarthritis and when overexpressed, it promotes cell proliferation, reduces apoptosis and facilitates inflammatory response [19].