The liver is a “CD95-sensitive” organ in which various cells express CD95 on their surfaces.60 CD95-mediated apoptosis is crucially involved in autoimmune liver, alcoholic hepatitis, viral hepatitis and other liver diseases.61 The CD95 agonistic antibody Jo2 activates CD95-dependent apoptosis signals and directly induces liver injury. This evidence concerns the gene FAS and animal viral hepatitis.