Activation of CD95/CD95L signaling directly induces liver damage in mice.6 CD95/CD95L-dependent hepatocyte apoptosis is widely involved in a variety of liver diseases,7,8 such as alcohol-induced liver injury,9 viral hepatitis,10,11 and hepatocellular carcinoma.12 Various factors, such as pathogen infection, cell death, antigen stimulation, cytokine stimulation, living conditions, and variations in the intestinal flora, greatly affect CD95 liver expression.13–16. The gene discussed is FAS; the disease is hepatocellular carcinoma.