ConA-induced liver injury is a T cell-mediated and IFN-γ-dependent autoimmune liver disease in mice.35 Previous studies showed that NKT and CD4 + T cells aggravated ConA-induced liver injury by producing IFN-γ.36,59 However, our data showed that the difference in ConA-induced liver injury caused by Gen and Van treatment was independent of IFN-γ, NKT and CD4 + T cells. The gene discussed is IFNG; the disease is autoimmune hepatitis.