Concentrations of Gamitrinib that trigger tumor cell killing in culture (IC50 ~1–4 μM)28,30 did not inhibit cytochrome P450 isoforms CYP1A2 (IC50, 32.9 μM), CYP2A6 (IC50, 24 μM), CYP2B6 (IC50, 16 μM), and CYP2C8 (IC50, 8 μM) (Supplementary Figure S2). Here, CYP2C8 is linked to neoplasm.