TGFB1 and familial pancreatic carcinoma: We further designed a GSH‐responsive mesoporous silica nano‐formulation (dMSN‐SB) that inhibits intratumoral TGF‐β signaling, promotes TAN polarization toward the anti‐tumor N1 phenotypes, and subsequently enhances pancreatic cancer response to combined IRE and αPD1 therapy.