The present study aimed to evaluate the expression of MAP1LC3B (OMIM accession number: * 609604), ATG5 (OMIM accession number: * 604261), ATG10 (OMIM accession number: * 610800), RB1CC1 (OMIM accession number: * 606837), and AMBRA1 (OMIM accession number: * 611359) genes as the main genes in the autophagy pathway at diagnosis and in the CR and relapse phases of AML. The gene discussed is MAP1LC3B; the disease is acute myeloid leukemia.