APP is the precursor protein for Aβ, and these mice develop Aβ plaques in the cortex and hippocampus at approximately 3–4 months of age (Radde et al., 2006), followed by reactive gliosis and proinflammatory cytokine release (Lee et al., 2010; Radde et al., 2006), synaptic loss (Bittner et al., 2012), neuronal loss in the dentate gyrus (Rupp et al., 2011), hippocampal LTP/LTD impairments (Gengler et al., 2010) and cognitive impairment (Webster et al., 2013), all consistent with AD. This evidence concerns the gene APP and Cognitive impairment.