PSEN2 and Alzheimer disease: Wild‐type (WT) mice do not normally develop AD‐type pathology; hence, human genes consistent with fAD (e.g., amyloid precursor protein [APP], presenilin 1 [PS1] and presenilin 2 [PS2]) are commonly incorporated into mouse genomes to induce AD pathology in Tg mouse models (Balu et al., 2019).