These techniques have helped identify genetic influences that vary from low risk (e.g., CR1, CD33, CD2AP, etc.), to medium risk (e.g., ADAM12, PLD3, ABCA7, etc.), high risk (e.g., APOE, TREM2 and SORL1, etc.)and causal (e.g., APP, PS1 and PS2) associations with AD. The gene discussed is APP; the disease is Alzheimer disease.