MAPT and Hyperglycemia: Peripheral STZ and the resulting hyperglycaemia have been shown to increase APP protein expression in APP/PS1 mice, thus promoting Aβ generation (Yang et al., 2013) and directly exacerbate Aβ and tau pathologies (Arnold et al., 2018; Ferreira et al., 2018; Murtishaw et al., 2018; Yang et al., 2013).