Despite the increased risk in APOE‐4 human carriers, Tg fAD mice do not closely mimic the effects of human APOE isoforms (Balu et al., 2019), and a majority of Tg fAD mouse models use murine APOE instead of human APOE; this presents a limitation when investigating Aβ accumulation, synaptic integrity and neuroinflammation seen in AD (Balu et al., 2019). The gene discussed is APOE; the disease is Alzheimer disease.