MAPT and Alzheimer disease: The pathological hallmarks of AD include amyloid‐beta (Aβ) protein plaques composed of fibrillar Aβ (Hardy & Higgins, 1992; Hyman et al., 2012), neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein (Grundke‐Iqbal et al., 1986; Serrano‐Pozo et al., 2011), and chronic neuroinflammation, or a sustained immune response in the brain, that promotes and accelerates both Aβ and tau pathologies (Heneka et al., 2015; Kinney et al., 2018; Millington et al., 2014).